Scientific Publications

  Comparative study of stress and immune-related transcript outcomes triggered by Vibrio anguillarum bacterin and air exposure stress in liver and spleen of gilthead seabream (Sparus aurata), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss)
Fish & Shellfish Immunology, Volume 86, March 2019
  Dissecting the immune pathways stimulated following injection vaccination of rainbow trout (Oncorhynchus mykiss) against enteric redmouth disease (ERMDD).
Fish & Shellfish Immunology, Volume 85, February 2019
  Pichia pastoris yeast as a vehicle for oral vaccination of larval and adult teleosts
Fish & Shellfish Immunology, Volume 85, February 2019
  What could be the mechanisms of immunological memory in fish?
Fish & Shellfish Immunology, Volume 85, February 2019

  New cell lines for efficient propagation of koi herpesvirus and infectious salmon anaemia virus
Journal of Fish Diseases, Volume 42, issue 2, February 2019
Preface to the special issue ‘targeting fish vaccination’
Fish & Shellfish Immunology, February 2019
Studies on the Use of Flagellin as an Immunostimulant and Vaccine Adjuvant in Fish Aquaculture
Front. Immunol., 09 January 2019
Comparative Immune- and Stress-Related Transcript Response Induced by Air Exposure and Vibrio anguillarum Bacterin in Rainbow Trout (Oncorhynchus mykiss) and Gilthead Seabream (Sparus aurata) Mucosal Surfaces
Front. Immunol., 02 May 2018
  Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional Characterization of Two Divergent IL2 Paralogs in Salmonids

Front. Immunol., 26 July 2018
Intra-muscular and oral vaccination using a Koi Herpesvirus ORF25 DNA vaccine does not confer protection in common carp (Cyprinus carpio L.)
Fish & Shellfish Immunology, March 2018
Vaccination of carp against SVCV with an oral DNA vaccine or an insect cells-based subunit vaccine
Fish & Shellfish Immunology, March 2018
  Aluminum adjuvant potentiates gilthead seabream immune responses but
induces toxicity in splenic melanomacrophage centers
Fish & Shellfish Immunology, March 2018
  Fish Lymphocytes: An Evolutionary Equivalent of Mammalian Innate-Like Lymphocytes?
Frontiers in Immunology 
Identification of the First Teleost CD5 Molecule: Additional Evidence on Phenotypical and Functional Similarities between Fish IgM+ B Cells and Mammalian B1 Cells
Journal of Immunology 
  Evolution of Th2 responses: characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity
Scientific Reports Vol. 7/Issue 1 (2017)
Modulatory in vitro effect of stress hormones on the cytokine response of rainbow trout and gilthead sea bream head kidney stimulated with Vibrio anguillarum bacterin
Fish & Shellfish Immunology 70 · September 2017
  Immunoglobulin T from sea bass (Dicentrarchus labrax L.): molecular characterization, tissue localization and expression after nodavirus infection
BMC Molecular Biology Vol. 18/Issue 1 (2017)
Efficacy of a polyvalent immersion vaccine against Flavobacterium psychrophilum and evaluation of immune response to vaccination in rainbow trout fry (Onchorynchus mykiss L.) 
Veterinary Research Vol. 48/Issue 1 (2017)
  Vaccination and immune responses of European sea bass ( Dicentrarchus labrax L.) against betanodavirus
Fish and Shellfish Immunology (2017)
  Antimicrobial susceptibility of Flavobacterium psychrophilum isolates from the United Kingdom
Journal of Fish Diseases (2017)
  Intramuscular DNA Vaccination of Juvenile Carp against Spring Viremia of Carp Virus Induces Full Protection and Establishes a Virus-Specific B and T Cell Response
Frontiers in Immunology Vol. 8 (2017)
  Lack of in vivo cross-protection of two different betanodavirus species RGNNV and SJNNV in European sea bass Dicentrachus labrax
Fish and Shellfish Immunology (2017)
  Efficacy and safety of a non-mineral oil adjuvanted injectable vaccine for the protection of Atlantic salmon ( Salmo salar L.) against Flavobacterium psychrophilum
Fish and Shellfish Immunology (2017)
  Effect of oral booster vaccination of rainbow trout against Yersinia ruckeri depends on type of primary immunization
Fish and Shellfish Immunology (2017)
  Describing the diversity of Ag specific receptors in vertebrates: Contribution of repertoire deep sequencing 
Developmental and Comparative Immunology Vol. 75 (2017)
Different IgM + B cell subpopulations residing within the peritoneal cavity of vaccinated rainbow trout are differently regulated by BAFF
Fish and Shellfish Immunology (2017)
Castro el al DCI 2017 peritoneo Expansion and differentiation of IgMþ B cells in the rainbow trout
peritoneal cavity in response to different antigens
Developmental and Comparative Immunology Volume 70, May 2017
 Presentación de PowerPoint The BAFF / APRIL axis plays an important role in virus-induced peritoneal responses in rainbow trout
Fish & Shellfish Immunology, Volume 64, May 2017
  Secondary immune response of rainbow trout following repeated immersion vaccination
Journal of Fish Diseases (2017)
Evolution of lymphocytes. Immunoglobulin T of the teleost sea bass (Dicentrarchus labrax): Quantitation of gene expressing and immunoreactive cells
Fish and Shellfish Immunology Vol. 63 (2017)
 fgene-08-00024-g005 Studying the Genetics of Resistance to CyHV-3 Disease Using Introgression from Feral to Cultured Common Carp Strains
Front. Genet., 10 March 2017
  Characterization of BAFF and APRIL subfamily receptors in rainbow trout (Oncorhynchus mykiss). Potential role of the BAFF / APRIL axis in the pathogenesis of proliferative kidney disease
PLos One Vol. 12/Issue 3 (2017)
  Genetic and serological diversity of Flavobacterium psychrophilum isolates from salmonids in United Kingdom
Veterinary Microbiology, Volume 201 (2017)
biology-04-00814-g003a IL10, A Tale of an Evolutionarily Conserved Cytokine across Vertebrates
Critical Reviews™ in Immunology, 36(2): 99-129 (2016)
Field_studies ERM booster vaccination of rainbow trout using diluted bacterin: Field studies
Aquaculture, Vol. 464 (2016)
a formalin-inactivated A formalin-inactivated immunogen against viral encephalopathy and retinopathy (VER) disease in European sea bass (Dicentrarchus labrax): Immunological and protection effects
Veterinary Research, Vol. 47/ issue 1 (2016)
oncotarget-07-10917-g011 First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities
ncotarget, publ. online 2016, march 8
  Nanostructured recombinant cytokines: A highly stable alternative to short-lived prophylactics
Biomaterials, Vol. 107 (2016)
fimmu-07-00637-g003 Differential Modulation of IgT and IgM upon Parasitic, Bacterial, Viral, and Dietary Challenges in a Perciform Fish
Frontiers in Immunology, Vol. 7 (2016)
Frontiers in Immunology, vol. 3 (2016)
biology-04-00814-g003a Along the Axis between Type 1 and Type 2 Immunity; Principles Conserved in Evolution from Fish to Mammals
PLos One, Vol. 10/ Issue 7 (2015)
Oral vaccination of fish: Lessons from humans and veterinary species
Developmental and Comparative Immunology Vol. 64 (2016)
 CanVHSVirus Can VHS Virus Bypass the Protective Immunity Induced by DNA Vaccination in Rainbow Trout?
PLos One, Vol. 11 / Issue 4 (2016)
 Microsoft PowerPoint - yfsim_4123_yoon et al figures 110816 Analysis of interferon gamma protein expression in zebrafish (Danio rerio)
Fish and Shellfish Immunology, Vol. 57 (2016)
 2016-IL-6-B-cells Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM+ B Cells in the Absence of Germinal Centers
Scientific Reports, Vol. 6 (2016)
 Anna Deep seq 2016 Ultra-deep sequencing of VHSV isolates contributes to understanding the role of viral quasispecies
Veterinary Research, Vol. 47/ issue 1 (2016)
F3_medium Novel Teleost CD4-Bearing Cell Populations Provide Insights into the Evolutionary Origins and Primordial Roles of CD4+ Lymphocytes and CD4+ Macrophages
Journal of Immunology Vol. 196/Issue 11 (2016)
 Water temperature affects pathogenicity of different Water temperature affects pathogenicity of different betanodavirus genotypes in experimentally challenged Dicentrarchus labrax
Diseases of Aquatic Organisms Vol. 119/Issue 3 (2016)
12864_2016_2739_Fig1_HTML A de novo transcriptome analysis shows that modulation of the JAK-STAT signaling pathway by salmonid alphavirus subtype 3 favors virus replication in macrophage/dendritic-like TO-cells,
BMC Genomics, Vol. 17/Issue 1 (2016)
1-s2_0-S0264410X15005782-gr5 Involvement of two microRNAs in the early immune response to DNA vaccination against a fish rhabdovirus,
Vaccine, Vol. 33/Issue 28 (2015)
 zee0051684660002 Cross Talk Between Growth and Immunity: Coupling of the IGF Axis to Conserved Cytokine Pathways in Rainbow Trout,
Endocrinology, Vol. 157/Issue 5 (2016)
Figures FINAL-NEW(2016) Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
Nature Communications Vol. 7 (2016)
Role of histamine in the regulation of intestinal immunity in fish
Developmental and Comparative Immunology (2016)
jfd12440-fig-0003 Betanodavirus ability to infect juvenile European sea bass, Dicentrarchus labrax, at different water salinity 
Journal of Fish Diseases (2016)
viruses-08-00114 De Novo Transcriptome Analysis Shows That SAV-3 Infection Upregulates Pattern Recognition Receptors of the Endosomal Toll-Like and RIG-I-Like Receptor Signaling Pathways in Macrophage/Dendritic Like TO-Cells,
Viruses, Vol. 8/Issue 4 (2016)
PowerPoint Presentation Re-examination of the rainbow trout (Oncorhynchus mykiss) immune response to flagellin: Yersinia ruckeri flagellin is a potent activator of acute phase proteins, anti-microbial peptides and pro-inflammatory cytokines in vitro,
Developmental and Comparative Immunology, Vol. 57 (2015)
8163-124111-3-PB Rainbow trout CK9, a CCL25-like ancient chemokine that attracts and regulates B cells and macrophages, the main antigen presenting cells in fish,
Oncotarget, Vol. 7, No. 14 (2016)
journal_pone_0148467_g004 A Systematic Approach towards Optimizing a Cohabitation Challenge Model for Infectious Pancreatic Necrosis Virus in Atlantic Salmon (Salmo salar L.),
PLoS One, Vol. 11/Issue 2 (2016)
tcellimmunity T cell immunity in the teleost digestive tract,
Developmental and Comparative Immunology, 2016
prot24946-fig-0001 High-resolution crystal structures leverage protein binding affinity predictions,
Proteins: Structure, Function and Genetics, Vol. 84/Issue 1 (2016)
Polarization of immune responses in fish: The ‘macrophages first’ point of view,
Molecular Immunology, Vol. 69 (2015)
1-s2_0-S016158901530064X-gr1 Alternative adaptive immunity strategies: coelacanth, cod and shark immunity,
Molecular Immunology, Vol. 69 (2016)
Recent findings on vertebrate developmental immunity using the zebrafish model,
Molecular Immunology, Vol. 69 (2016)
Unique Features of Fish Immune Repertoires: Particularities of Adaptive Immunity Within the Largest Group of Vertebrates

Print Effects of adjuvant Montanide™ ISA 763 A VG in rainbow trout injection vaccinated against Yersinia ruckeri,
Fish and Shellfish Immunology, Vol. 47/Issue 2 (2015)
1-s2_0-S1050464815301418-gr1 A synthetic peptide derived from the D1 domain of flagellin induced the expression of proinflammatory cytokines in fish macrophages,
Fish and Shellfish Immunology, Vol. 47/Issue 1 (2015)
jfd12415-fig-0005 Quantitative immunoenzymatic detection of viral encephalopathy and retinopathy virus (betanodavirus) in sea bass Dicentrarchus labrax,
Journal of Fish Diseases, 2015 Nov 27
An Overview of Challenges Limiting the Design of Protective Mucosal Vaccines for Finfish,
Frontiers in Immunology, Vol. 6 (2015)
srep15458-f2 Disparate developmental patterns of immune responses to bacterial and viral infections in fish,
Scientific Reports, Vol. 5 (2015)
fimmu-06-00519-g001 Oral Vaccination of Fish – Antigen Preparations, Uptake, and Immune Induction,
Frontiers in Immunology, Vol. 6 (2015)
fimmu-06-00512-g002 Selective Manipulation of the Gut Microbiota Improves Immune Status in Vertebrates,
Frontiers in Immunology, Vol. 6 (2015)
A Review of the Immunological Mechanisms Following Mucosal Vaccination of Finfish,
Frontiers in Immunology, Vol. 6 (2015)
F2_large Identification of Teleost Skin CD8 + Dendritic-like Cells, Representing a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells,
Journal of Immunology, Vol. 195/Issue 4 (2015)
fimmu-06-00354-g001 Mucosal Immunity and B Cells in Teleosts: Effect of Vaccination and Stress, Frontiers in Immunology, Vol. 6 (2015)
251_2015_838_Fig4_HTML Identification of the salmonid IL-17A/F1a/b, IL-17A/F2b, IL-17A/F3 and IL-17N genes and analysis of their expression following in vitro stimulation and infection,
Immunogenetics, Vol. 67/Issue 7 (2015)
Microsoft PowerPoint - figures.pptx Molecular characterization of CD9 and CD63, two tetraspanin family members expressed in trout B lymphocytes,
Developmental and Comparative Immunology, Vol. 51/Issue 1 (2015)
Fig 4_IHC Comparative evaluation of infection methods and environmental factors on challenge success: Aeromonas salmonicida infection in vaccinated rainbow trout,
Fish and Shellfish Immunology, Vol. 44/Issue 2 (2015)
1-s2_0-S0044848615000538-gr2 Booster immersion vaccination using diluted Yersinia ruckeri bacterin confers protection against in rainbow trout,
Aquaculture, Vol. 440 (2015)
1-s2_0-S1050464814004380-gr6 MHC II-� chain gene expression studies define the regional organization of the thymus in the developing bony fish Dicentrarchus labrax (L.),
Fish and Shellfish Immunology, Vol. 42/Issue 2 (2015)
12864_2015_1302_Fig5_HTML De novo assembly and transcriptome analysis of Atlantic salmon macrophage/dendritic-like TO cells following type I IFN treatment and Salmonid alphavirus subtype-3 infection,
BMC Genomics, Vol. 16/Issue 1 (2015)
JIR2015-960859_001 A Review of Intra- and Extracellular Antigen Delivery Systems for Virus Vaccines of Finfish,
Clinical and Developmental Immunology, Vol. 2015
1-s2_0-S0145305X14001967-dci2239-fig-0005 T cell transcripts and T cell activities in the gills of the teleost fish sea bass (Dicentrarchus labrax),
Developmental and Comparative Immunology, Vol. 47/Issue 2 (2014)
F4_medium Carp Il10 Has Anti-Inflammatory Activities on Phagocytes, Promotes Proliferation of Memory T Cells, and Regulates B Cell Differentiation and Antibody Secretion,
Journal of Immunology, published online 21 November 2014
Flagellin from Marinobacter algicola and Vibrio vulnificus activates the innate immune response of gilthead seabream,
Developmental and Comparative Immunology, Vol. 47/Issue 1 (2014)
1-s2_0-S0161589014001217-gr3 Molecular characterization, gene structure and antibacterial activity of a g-type lysozyme from the European sea bass (Dicentrarchus labrax L.),
Molecular Immunology, Vol. 62/Issue 1 (2014)
1-s2_0-S105046481400223X-gr4 Identification and characterisation of the IL-27 p28 subunits in fish: Cloning and comparative expression analysis of two p28 paralogues in Atlantic salmon Salmo salar,
Fish and Shellfish Immunology, Vol. 41/Issue 1 (2014)
journal_pone_0111084_g001 Early Immune Responses in Rainbow Trout Liver upon Viral Hemorrhagic Septicemia Virus (VHSV) Infection,
PLoS One, Vol. 9/Issue 10 (2014)
Immunological Characterization of the Teleost Adipose Tissue and Its Modulation in Response to Viral Infection and Fat-Content in the Diet,
PLoS One, Vol. 9/Issue 10 (2014)
Isolation of the Atlantic salmon salmo salar Signal Transduction Isolation and activity of the promoters for STAT1 and 2 in Atlantic salmon Salmo salar,
Fish and Shellfish Immunology, Vol. 40/Issue 2 (2014)
1-s2_0-S0145305X14000366-gr2 Comparative studies of Toll-like receptor signalling using zebrafish, Developmental and Comparative Immunology, Vol. 46/Issue 1 (2014)
1-s2_0-S0145305X13003261-gr2 Transcriptomic responses in rainbow trout gills upon infection with viral hemorrhagic septicemia virus (VHSV),
Developmental and Comparative Immunology, Vol. 44/Issue 1 (2014)
Dev Comp Immunol. 2013 Dec 24 Modulation of genes related to the recruitment of immune cells in the digestive tract of trout experimentally infected with infectious pancreatic necrosis virus (IPNV) or orally vaccinated,
Developmental and Comparative Immunology, Vol. 44/Issue 1 (2013)
untitled Ligand specificities of Toll-like receptors in fish: Indications from infection studies,
Developmental and Comparative Immunology, Vol. 43/Issue 2 (2014)
251_2013_751_Fig2_HTML Identification and functional characterization of nonmammalian Toll-like receptor 20,
Immunogenetics, Vol. 66/Issue 2 (2014)
Slide 1 The cytokine networks of adaptive immunity in fish,
Fish and Shellfish Immunology, Vol. 35/Issue 6 (2013)
1-s2_0-S0264410X1301596X-gr2 DNA vaccination against a fish rhabdovirus promotes an early chemokine-related recruitment of B cells to the muscle,
Vaccine, 32(10) (2014)
Comparative evaluation of administration methods for a vaccine protecting rainbow trout against Yersinia ruckeri O1 biotype 2 infections,
Veterinary Immunology and Immunopathology, Vol. 154/Issue 1-2 (2013)
1-s2_0-S0161589013004781-gr2 Accessory molecules for Toll-like receptors in Teleost fish.Identification of TLR4 interactor with leucine-rich repeats (TRIL),
Molecular Immunology, 56 (2013)
isfsi Targeted disease prophylaxis in European fish farming (TargetFish),
Fish and Shellfish Immunology, Volume 34, Issue 6 (2013)
Contrasted TCRβ Diversity of CD8+ and CD8− T Cells in Rainbow Trout, PLoS One, Volume 8 | Issue 4 | e60175 (2013)
fimmu-04-00028-g002 The astonishing diversity of Ig classes and B cell repertoires in teleost fish, Frontiers in Immunology, Feb 13;4:28 (2013)